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Article

Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011

Zaiss Dietmar M W, Bekker Cornelis P J, Gröne Andrea, Lie Benedicte A, Sijts Alice J A M

Abstract excerpt

Exposure of cells to inflammatory cytokines induces the expression of three proteasome immunosubunits, two of which are encoded in the MHC class II region. The induced subunits replace their constitutive homologs in newly formed "so-called" immunoproteasomes. Immunosubunit incorporation enhances the proteasome's proteolytic activity and modifies the proteasome's cleavage-site preferences, which improves the...

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Source

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Identifiers

PMID: 21804012
DOI: 10.4049/jimmunol.1101003
PMCID: PMC3159700

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases.PMID 21804012Read ↗

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A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation PathwaysSemantic proximity Read ↗

The Ubiquitin–Proteasome System in Immune CellsSemantic proximity Read ↗

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