Article
Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.
American journal of human genetics - 1 May 2006
McMahon Francis J, Buervenich Silvia, Charney Dennis, Lipsky Robert, Rush A John, Wilson Alexander F, Sorant Alexa J M, Papanicolaou George J, Laje Gonzalo, Fava Maurizio, Trivedi Madhukar H, Wisniewski Stephen R, Manji Husseini
Abstract excerpt
Depressive disorders account for a large and increasing global burden of disease. Although the condition of many patients improves with medication, only a minority experience full remission, and patients whose condition responds to one medication may not have a response to others. Individual variation in antidepressant treatment outcome is, at present, unpredictable but may have a partial genetic basis. We...
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