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Article

The interplay between SLC6A4 and HTR1A genetic variants that may lead to antidepressant failure.

The pharmacogenomics journal - 7 May 2025

Hanna Sandra, Faiz Mark, Ahmed Sanjida, Hsieh Cindy, Temkit Sara, Nunez Cristina, Zhou Feng

Abstract excerpt

The serotonin transporter (SLC6A4) and the serotonin autoreceptor (HTR1A) are two of the most extensively studied genes in the field of psychiatry, and their variants have been implicated in antidepressant response, specifically with selective serotonin reuptake inhibitors (SSRIs) which are widely regarded as the first-line medications for depression and anxiety. Variants of SLC6A4 and HTR1A have also been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Serotonin, 5-HT1A

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Source

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Identifiers

PMID: 40335484
DOI: 10.1038/s41397-025-00370-5
PMCID: PMC12058508

Genes

HTR1A
SLC6A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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