Article
STAT3 positively regulates an early step in B-cell development.
Blood - 1 Nov 2006
Chou Wei-Chun, Levy David E, Lee Chien-Kuo
Abstract excerpt
Transcription factors are critical for instructing the development of B lymphocytes from multipotential progenitor cells in the bone marrow (BM). Here, we show that the absence of STAT3 impaired B-cell development. Mice selectively lacking STAT3 in BM progenitor cells displayed reduced numbers of mature B cells, both in the BM and in the periphery. The reduction in the B-cell compartment included reduced...
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