Article
The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly.
Birth defects research. Part A, Clinical and molecular teratology - 1 Feb 2010
Burren Katie A, Scott John M, Copp Andrew J, Greene Nicholas D E
Abstract excerpt
BACKGROUND: Suboptimal maternal folate status is considered a risk factor for neural tube defects (NTDs). However, the relationship between dietary folate status and risk of NTDs appears complex, as experimentally induced folate deficiency is insufficient to cause NTDs in nonmutant mice. In contrast, folate deficiency can exacerbate the effect of an NTD-causing mutation, as in splotch mice. The purpose of the...
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