Dietary methionine does not reduce penetrance in curly tail mice but causes a phenotype-specific decrease in embryonic growth.

Abstract excerpt

The mouse mutation, curly tail, has incomplete penetrance and variable expression. Approximately 60% of the mice have a curly tail (CT), from which up to 20% may have lumbosacral spina bifida. Approximately 40% are normal, with a straight tail (ST). We tested whether L-methionine, which reduces the penetrance of neural tube defects in the Axd mouse mutant, has beneficial effects in the curly tail mutant. A single...

Topics

• Animals
• Diet
• Dose-Response Relationship, Drug
• Embryonic and Fetal Development
• Female
• Homocysteine
• Male
• Methionine
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA