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Article

Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants

31 Dec 2008

Abstract excerpt

Almost 30 years after the initial study by Richard W. Smithells and coworkers, it is still unknown how maternal periconceptional folic acid supplementation prevents human neural tube defects (NTDs). In this article, questions about human NTD prevention are considered in relation to three groups of mouse models: NTD mutants that respond to folate, NTD mutants and strains that do not respond to folate, and mutants...

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PMID: 19117321
DOI: 10.1002/bdra.20552

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