Article
Magnetization transfer imaging in 'premanifest' Huntington's disease.
Journal of neurology - 1 Mar 2010
Jurgens Caroline K, Bos Reineke, Luyendijk Jasper, Witjes-Ané Marie-Noëlle W, van der Grond Jeroen, Middelkoop Huub A M, Roos Raymund A C
Abstract excerpt
To investigate whether magnetization transfer imaging (MTI) is a useful detector of diffuse brain abnormalities in 'premanifest' carriers of the Huntington's disease (HD) gene mutation. Furthermore we examined the relations between MTI, clinical measures and CAG repeat length. Sixteen premanifest carriers of the HD gene without motor manifestation and 14 non-carriers underwent a clinical evaluation and a MRI...
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