Article
GSK3beta regulates differentiation and growth arrest in glioblastoma.
PloS one - 13 Oct 2009
Korur Serdar, Huber Roland M, Sivasankaran Balasubramanian, Petrich Michael, Morin Pier, Hemmings Brian A, Merlo Adrian, Lino Maria Maddalena
Abstract excerpt
Cancers are driven by a population of cells with the stem cell properties of self-renewal and unlimited growth. As a subpopulation within the tumor mass, these cells are believed to constitute a tumor cell reservoir. Pathways controlling the renewal of normal stem cells are deregulated in cancer. The polycomb group gene Bmi1, which is required for neural stem cell self-renewal and also controls anti-oxidant...
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