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Article

Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ -catenin pathway

28 Jul 2013

Abstract excerpt

BACKGROUND: Glioblastoma multiforme stem cells display a highly chemoresistant phenotype, whose molecular basis is poorly known. We aim to clarify this issue and to investigate the effects of temozolomide on chemoresistant stem cells. METHODS: A panel of human glioblastoma cultures, grown as stem cells (neurospheres) and adherent cells, was used. RESULTS: Neurospheres had a multidrug resistant phenotype compared...

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PMID: 23897632
DOI: 10.1093/neuonc/not104

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