Article
SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes.
PloS one - 1 Jan 2011
Schürch Anita C, Kremer Kristin, Hendriks Amber C A, Freyee Benthe, McEvoy Christopher R E, van Crevel Reinout, Boeree Martin J, van Helden Paul, Warren Robin M, Siezen Roland J, van Soolingen Dick
Abstract excerpt
The Beijing strain is one of the most successful genotypes of Mycobacterium tuberculosis worldwide and appears to be highly homogenous according to existing genotyping methods. To type Beijing strains reliably we developed a robust typing scheme using single nucleotide polymorphisms (SNPs) and regions of difference (RDs) derived from whole-genome sequencing data of eight Beijing strains. SNP/RD typing of 259 M....
Topics
- Algorithms
- Bacterial Typing Techniques
- Cluster Analysis
- Genes, Bacterial
- Genome, Bacterial
- Genotype
- Likelihood Functions
- Models, Statistical
- Molecular Epidemiology
- Mycobacterium tuberculosis
- Phylogeny
- Phylogeography