Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies.

PloS one - 12 Nov 2009

Comas Iñaki, Homolka Susanne, Niemann Stefan, Gagneux Sebastien

Abstract excerpt

Because genetically monomorphic bacterial pathogens harbour little DNA sequence diversity, most current genotyping techniques used to study the epidemiology of these organisms are based on mobile or repetitive genetic elements. Molecular markers commonly used in these bacteria include Clustered Regulatory Short Palindromic Repeats (CRISPR) and Variable Number Tandem Repeats (VNTR). These methods are also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Typing Techniques
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to DNA Fingerprinting

Share to DNA Transposable Elements

Share to Genetic Markers

Share to Mycobacterium tuberculosis

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 19915672
DOI: 10.1371/journal.pone.0007815
PMCID: PMC2772813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies.PMID 19915672Read ↗

Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set.Semantic proximity Read ↗

Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats.Semantic proximity Read ↗

Whole-genome single nucleotide variant phylogenetic analysis of Mycobacterium tuberculosis Lineage 1 in endemic regions of Asia and Africa.Semantic proximity Read ↗

The use of mycobacterial interspersed repetitive unit typing and whole genome sequencing to inform tuberculosis prevention and control activities.Semantic proximity Read ↗

Evolution of short sequence repeats in Mycobacterium tuberculosis.Semantic proximity Read ↗

Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method.Semantic proximity Read ↗

Consistency of Mycobacterium tuberculosis Complex Spoligotyping between the Membrane-Based Method and In Silico Approach.Semantic proximity Read ↗

Associations between Mycobacterium tuberculosis strains and phenotypes.Semantic proximity Read ↗

Genetic markers, genotyping methods & next generation sequencing in Mycobacterium tuberculosis.Semantic proximity Read ↗

Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiologySemantic proximity Read ↗

A Comprehensive Map of Mycobacterium tuberculosis Complex Regions of Difference.Semantic proximity Read ↗

Utility and evaluation of new variable-number tandem-repeat systems for genotyping mycobacterial tuberculosis isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.