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Article

Replication study implicates COMT val158met polymorphism as a modulator of probabilistic reward learning.

Genes, brain, and behavior - 1 Jul 2015

Lancaster T M, Heerey E A, Mantripragada K, Linden D E J

Abstract excerpt

Previous studies suggest that a single nucleotide polymorphism in the catechol-O-methyltransferase (COMT) gene (val158met) may modulate reward-guided decision making in healthy individuals. The polymorphism affects dopamine catabolism and thus modulates prefrontal dopamine levels, which may lead to variation in individual responses to risk and reward. We previously showed, using tasks that index reward...

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Source

Identifiers

PMID: 26096878
DOI: 10.1111/gbb.12228

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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