Article
Effects of DRD2/ANKK1 and COMT Val158Met polymorphisms on stabilization against and adaptation to unexpected events.
Cerebral cortex (New York, N.Y. : 1991) - 8 Dec 2022
Trempler Ima, Binder Ellen, Reuter Martin, Plieger Thomas, Standke Isabel, Mecklenbrauck Falko, Meinert Susanne, Forstner Andreas J, Nöthen Markus M, Rietschel Marcella, Stürmer Sophie, Dannlowski Udo, Tittgemeyer Marc, Lencer Rebekka, Fink Gereon R, Schubotz Ricarda I
Abstract excerpt
Genetic variations affecting dopaminergic neuromodulation such as the DRD2/ANKK1 and the COMT Val158Met polymorphisms contribute to goal-directed behavior that requires a balance between stabilization and updating of current states and behaviors. Dopamine is also thought to be relevant for encoding of surprise signals to sensory input and adaptive learning. A link between goal-directed behavior and learning from...
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