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Article

Calcium bridge triggers capsid disassembly in the cell entry process of simian virus 40.

The Journal of biological chemistry - 11 Dec 2009

Kawano Masa-Aki, Xing Li, Tsukamoto Hiroko, Inoue Takamasa, Handa Hiroshi, Cheng R Holland

Abstract excerpt

The calcium bridge between the pentamers of polyoma viruses maintains capsid metastability. It has been shown that viral infection is profoundly inhibited by the substitution of lysine for glutamate in one calcium-binding residue of the SV40 capsid protein, VP1. However, it is unclear how the cal...

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Identifiers

PMID: 19822519
DOI: 10.1074/jbc.M109.015107
PMCID: PMC2787333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19822519-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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