Article
Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Aug 2009
Tsujioka Hiroshi, Hachisuga Toru, Fukuoka Miyoko, Ueda Taeko, Miyahara Daisuke, Horiuchi Shinji, Shirota Kyoko, Yoshizato Toshiyuki, Emoto Makoto, Miyamoto Shingo, Kawarabayashi Tatsuhiko
Abstract excerpt
INTRODUCTION: A high incidence of endometrial K-ras mutations has been reported in tamoxifen (TAM)-treated patients with breast cancer. We examined the changes in the frequency of the endometrial K-ras mutations after the cessation of TAM treatment. METHODS: DNA was extracted from fresh cytological or polypectomy samples of the endometrium in 28 patients who had undergone TAM treatment of breast cancer. Mutations...
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