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Article

Apoptosis as a possible candidate mechanism for removal of tamoxifen-related endometrial cells with KRAS mutations.

Anticancer research - 1 Aug 2010

Tsujioka Hiroshi, Hachisuga Toru, Hikita Shoko, Ueda Taeko, Yotsumoto Fusanori, Shirota Kyoko, Yoshizato Toshiyuki, Kawarabayashi Tatsuhiko, Kuroki Masahide, Miyamoto Shingo

Abstract excerpt

BACKGROUND: Endometrial cell KRAS mutations are frequent in tamoxifen (TAM)-treated breast cancer patients. We previously demonstrated that most KRAS mutations disappeared after TAM cessation, suggesting the existence of a removal mechanism for endometrial cells with KRAS mutation. Here, the role of apoptosis in this mechanism was investigated. PATIENTS AND METHODS: DNA was extracted from frozen endometrial...

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Source

Identifiers

PMID: 20871029

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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