The application of oligonucleotide probes to HLA class II typing of the DRB sub-region.

doi:10.1111/j.1399-0039.1990.tb01821.x

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Article

The application of oligonucleotide probes to HLA class II typing of the DRB sub-region.

Tissue antigens - 1 Oct 1990

Vaughan R W, Lanchbury J S, Marsh S G, Hall M A, Bodmer J G, Welsh K I

Abstract excerpt

A plan for DRB typing at the sequence level is detailed. Only one polymerase chain amplification reaction is needed and the application of a limited number of short oligonucleotide probes allows an almost complete definition of DRB alleles. The scheme was tested on 40 homozygous cell-lines selected to cover a wide range of specificities, and 40 RFLP-typed controls. The results are presented and discussed. The...

Topics

Alleles
Autoradiography
Base Sequence
DNA
HLA-DR Antigens
Heterozygote
Histocompatibility Antigens Class II
Histocompatibility Testing
Homozygote
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Oligonucleotide Probes

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Quaternary Ammonium Compounds

Source

Open in PubMed

Identifiers

PMID: 1981815
DOI: 10.1111/j.1399-0039.1990.tb01821.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1981815-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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