Article
HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British caucasoids.
Human immunology - 1 May 1992
Doherty D G, Vaughan R W, Donaldson P T, Mowat A P
Abstract excerpt
A precise method for comprehensive HLA DQA and DQB genotyping using gene amplification and hybridization with sequence-specific oligonucleotide (SSO) probes is described. Twenty-four SSO probes were used to detect all DQ allotypes defined by nucleotide sequence variation in the second exons of th...
Topics
- Adult
- Alleles
- Autoimmune Diseases
- Base Sequence
- Child
- Gene Frequency
- Genes, MHC Class II
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- HLA-DRB3 Chains
- HLA-DRB4 Chains
- HLA-DRB5 Chains
- Haplotypes
- Histocompatibility Antigens Class II