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Article

Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission.

Virology journal - 10 Oct 2009

Ngandu Nobubelo K, Seoighe Cathal, Scheffler Konrad

Abstract excerpt

BACKGROUND: The cytotoxic T-lymphocyte immune response is important in controlling HIV-1 replication in infected humans. In this immune pathway, viral peptides within infected cells are presented to T-lymphocytes by the polymorphic human leukocyte antigens (HLA). HLA alleles exert selective pressure on the peptide regions and immune escape mutations that occur at some of the targeted sites can enable the virus to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19818146
DOI: 10.1186/1743-422X-6-164
PMCID: PMC2765438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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