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Article

Evidence for selection at HIV host susceptibility genes in a West Central African human population.

BMC evolutionary biology - 6 Dec 2012

Zhao Kai, Ishida Yasuko, Oleksyk Taras K, Winkler Cheryl A, Roca Alfred L

Abstract excerpt

BACKGROUND: HIV-1 derives from multiple independent transfers of simian immunodeficiency virus (SIV) strains from chimpanzees to human populations. We hypothesized that human populations in west central Africa may have been exposed to SIV prior to the pandemic, and that previous outbreaks may have selected for genetic resistance to immunodeficiency viruses. To test this hypothesis, we examined the genomes of...

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Source

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Identifiers

PMID: 23217182
DOI: 10.1186/1471-2148-12-237
PMCID: PMC3537702

Genes

CUL5
TRIM5
CCR5
CXCR6

Provenance

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Semantic proximity does not establish scientific evidence.

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