Article
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Nature - 8 Oct 2009
Shah Sohrab P, Morin Ryan D, Khattra Jaswinder, Prentice Leah, Pugh Trevor, Burleigh Angela, Delaney Allen, Gelmon Karen, Guliany Ryan, Senz Janine, Steidl Christian, Holt Robert A, Jones Steven, Sun Mark, Leung Gillian, Moore Richard, Severson Tesa, Taylor Greg A, Teschendorff Andrew E, Tse Kane, Turashvili Gulisa, Varhol Richard, Warren René L, Watson Peter, Zhao Yongjun, Caldas Carlos, Huntsman David, Hirst Martin, Marra Marco A, Aparicio Samuel
Abstract excerpt
Recent advances in next generation sequencing have made it possible to precisely characterize all somatic coding mutations that occur during the development and progression of individual cancers. Here we used these approaches to sequence the genomes (>43-fold coverage) and transcriptomes of an oestrogen-receptor-alpha-positive metastatic lobular breast cancer at depth. We found 32 somatic non-synonymous coding...
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