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Article

Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.

The Journal of biological chemistry - 4 Dec 2009

Frizzell Kristine M, Gamble Matthew J, Berrocal Jhoanna G, Zhang Tong, Krishnakumar Raga, Cen Yana, Sauve Anthony A, Kraus W Lee

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) and poly(ADP-ribose) glycohydrolase (PARG) are enzymes that modify target proteins by the addition and removal, respectively, of ADP-ribose polymers. Although a role for PARP-1 in gene regulation has been well established, the role of PARG is less clear. To investigate how PARP-1 and PARG coordinately regulate global patterns of gene expression, we used short hairpin RNAs to...

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Identifiers

PMID: 19812418
DOI: 10.1074/jbc.M109.023879
PMCID: PMC2797163

Genes

PARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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