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Article

Oncogenic activity of poly (ADP-ribose) glycohydrolase

20 Nov 2018

Abstract excerpt

Poly (ADP-ribosylation), known as PARylation, is a post-translational modification catalyzed by poly (ADP-ribose) polymerases (PARP) and primarily removed by the enzyme poly (ADP-ribose) glycohydrolase (PARG). While the aberrant removal of post-translation modifications including phosphorylation and methylation has known tumorigenic effects, deregulation of PARylation has not been widely studied. Increased...

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PMID: 30459355
DOI: 10.1038/s41388-018-0568-6

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