Article
Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2009
Agrawal Hemant, Jacob Noam, Carreras Esther, Bajana Sandra, Putterman Chaim, Turner Sean, Neas Barbara, Mathian Alexis, Koss Michael N, Stohl William, Kovats Susan, Jacob Chaim O
Abstract excerpt
Type I IFNs are potent regulators of innate and adaptive immunity and are implicated in the pathogenesis of systemic lupus erythematosus. Here we report that clinical and pathological lupus nephritis and serum anti-nuclear Ab levels are greatly attenuated in New Zealand Mixed (NZM) 2328 mice deficient in type I IFN receptors (IFNAR). To determine whether the inflammatory environment in NZM 2328 mice leads to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.