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Article

Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2012

Sriram Uma, Varghese Linda, Bennett Heather L, Jog Neelakshi R, Shivers Debra K, Ning Yue, Behrens Edward M, Caricchio Roberto, Gallucci Stefania

Abstract excerpt

Patients with systemic lupus erythematosus show an overexpression of type I IFN-responsive genes that is referred to as "IFN signature." We found that B6.NZMSle1/Sle2/Sle3 (Sle1,2,3) lupus-prone mice also express an IFN signature compared with non-autoimmune C57BL/6 mice. In vitro, myeloid dendritic cells (mDCs) (GM-CSF bone marrow-derived dendritic cells; BMDCs) from Sle1,2,3 mice constitutively overexpressed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22661089
DOI: 10.4049/jimmunol.1101686
PMCID: PMC3381850

Genes

TLR7
TLR9
CXCL10
STAT1
STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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