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Article

Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1990

Leach R J, Magewu A N, Buckley J D, Benedict W F, Rother C, Murphree A L, Griegel S, Rajewsky M F, Jones P A

Abstract excerpt

The origins of the initial mutations in sporadic retinoblastoma were explored using polymorphic markers from chromosome 13q. The paternal chromosome was maintained in 3 of 3 informative bilateral tumors which had undergone reduction to homozygosity for regions of this chromosome. The paternal chromosome was maintained in 7 of 8 informative unilateral tumors which likewise demonstrated a reduction of homozygosity....

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PMID: 1981144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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