Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting.

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Article

Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1990

Leach R J, Magewu A N, Buckley J D, Benedict W F, Rother C, Murphree A L, Griegel S, Rajewsky M F, Jones P A

Abstract excerpt

The origins of the initial mutations in sporadic retinoblastoma were explored using polymorphic markers from chromosome 13q. The paternal chromosome was maintained in 3 of 3 informative bilateral tumors which had undergone reduction to homozygosity for regions of this chromosome. The paternal chr...

Topics

Alleles
Blotting, Southern
Chromosomes, Human, Pair 13
Heterozygote
Humans
Paternity
Polymorphism, Restriction Fragment Length
Retinoblastoma

Source

Open in PubMed

Identifiers

PMID: 1981144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1981144-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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