Article
Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma.
American journal of human genetics - 1 Nov 1996
Kato M V, Shimizu T, Nagayoshi M, Kaneko A, Sasaki M S, Ikawa Y
Abstract excerpt
Epidemiological and genetic studies of retinoblastoma (RB) suggested that imprinted genes might be genetically linked to the RB gene. In this study, we found that the human serotonin-receptor, HTR2, gene, which had been mapped nearby the RB gene on chromosome 13, was expressed only in human fibroblasts with a maternal allele and not in cells without a maternal allele. The 5' genomic region of the human HTR2 gene...
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