Unbiased transmission of mutant alleles at the human retinoblastoma locus.

doi:10.1007/BF00201561

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Article

Unbiased transmission of mutant alleles at the human retinoblastoma locus.

Human genetics - 1 Jun 1994

Seminara S B, Dryja T P

Abstract excerpt

The preferential transmission of the mutant allele to offspring from fathers who carry a germline mutation in the retinoblastoma gene was examined by analyzing 46 consecutive pedigrees. Among 75 offspring from 29 fathers, the ratio of carriers to noncarriers was 49%. Among the 106 offspring from...

Topics

Alleles
Female
Genes, Retinoblastoma
Genetic Carrier Screening
Humans
Male
Mutation
Pedigree

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