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Article

Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13.

International journal of cancer - 20 Feb 1995

Kato M V, Ishizaki K, Shimizu T, Toguchida J, Kaneko A, Sasaki M S

Abstract excerpt

Loss of heterozygosity (LOH) on chromosome 13, which is associated with the functional inactivation of the retinoblastoma (RB) gene, is critical for the development of RB. To date, we have found that LOH-negative tumors develop earlier than LOH-positive tumors in hereditary cases of RB, an observation which suggests that loss of one allele on chromosome 13 may be disadvantageous with respect to growth of RB...

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Identifiers

PMID: 7665245
DOI: 10.1002/ijc.2910640103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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