Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13.

doi:10.1002/ijc.2910640103

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Article

Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13.

International journal of cancer - 20 Feb 1995

Kato M V, Ishizaki K, Shimizu T, Toguchida J, Kaneko A, Sasaki M S

Abstract excerpt

Loss of heterozygosity (LOH) on chromosome 13, which is associated with the functional inactivation of the retinoblastoma (RB) gene, is critical for the development of RB. To date, we have found that LOH-negative tumors develop earlier than LOH-positive tumors in hereditary cases of RB, an observ...

Topics

Age Factors
Alleles
Base Sequence
Child, Preschool
Chromosomes, Human, Pair 13
DNA Primers
Eye Neoplasms
Female
Genetic Markers
Humans
Infant
Male
Molecular Sequence Data
Polymerase Chain Reaction
Retinoblastoma

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