Major histocompatibility complex genes influence the outcome of HIV infection. Ancestral haplotypes with C4 null alleles explain diverse HLA associations.

doi:10.1016/0198-8859(90)90042-n

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Article

Major histocompatibility complex genes influence the outcome of HIV infection. Ancestral haplotypes with C4 null alleles explain diverse HLA associations.

Human immunology - 1 Dec 1990

Cameron P U, Mallal S A, French M A, Dawkins R L

Abstract excerpt

Several alleles at multiple HLA loci have been found to be associated with infection with human immunodeficiency virus (HIV): HLA A1; B8, B35; Cw7, Cw4; DR1, DR3 and DQ1, are associated with particular disease manifestations and/or disease progression. Furthermore, in a pilot study we have shown...

Topics

Alleles
CD4-Positive T-Lymphocytes
Complement C4
Gene Frequency
HIV Infections
HIV Seropositivity
HLA Antigens
Haplotypes
Humans
Leukocyte Count
Male
Risk Factors

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