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Article

Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.

Circulation. Cardiovascular genetics - 1 Jan 2017

Chowdhury Biswajit, Xiang Bo, Liu Michelle, Hemming Richard, Dolinsky Vernon W, Triggs-Raine Barbara

Abstract excerpt

BACKGROUND: Hyaluronan (HA) is required for endothelial-to-mesenchymal transition and normal heart development in the mouse. Heart abnormalities in hyaluronidase 2 (HYAL2)-deficient (Hyal2-/- ) mice and humans suggested removal of HA is also important for normal heart development. We have performed longitudinal studies of heart structure and function in Hyal2-/- mice to determine when, and how, HYAL2 deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28196902
DOI: 10.1161/CIRCGENETICS.116.001598
PMCID: PMC5331876

Genes

HYAL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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