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Article

In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy.

Circulation. Cardiovascular imaging - 1 Sept 2009

Shoghi Kooresh I, Finck Brian N, Schechtman Kenneth B, Sharp Terry, Herrero Pilar, Gropler Robert J, Welch Michael J

Abstract excerpt

BACKGROUND: Cardiovascular disease is the leading cause of death among diabetic patients, with alteration in myocardial substrate metabolism being a likely contributor. We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus. METHODS AND RESULTS: The study used 18 male ZDF rats (fa/fa)...

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Identifiers

PMID: 19808625
DOI: 10.1161/CIRCIMAGING.108.843227
PMCID: PMC2760020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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