Article
Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the spontaneously hypertensive rat model of hypertrophy using small-animal PET/CT imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Nov 2013
Hernandez Andrew M, Huber Jennifer S, Murphy Stephanie T, Janabi Mustafa, Zeng Gengsheng L, Brennan Kathleen M, O'Neil James P, Seo Youngho, Gullberg Grant T
Abstract excerpt
UNLABELLED: Myocardial metabolic and perfusion imaging is a vital tool for understanding the physiologic consequences of heart failure. We used PET imaging to examine the longitudinal kinetics of (18)F-FDG and 14(R,S)-(18)F-fluoro-6-thia-heptadecanoic acid ((18)F-FTHA) as analogs of glucose and fatty acid (FA) to quantify metabolic substrate shifts with the spontaneously hypertensive rat (SHR) as a model of left...
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