Article
Normalizing the metabolic phenotype after myocardial infarction: impact of subchronic high fat feeding.
Journal of molecular and cellular cardiology - 1 Jul 2012
Berthiaume Jessica M, Young Martin E, Chen Xiaoqin, McElfresh Tracy A, Yu Xin, Chandler Margaret P
Abstract excerpt
The normal heart relies primarily on the oxidation of fatty acids (FA) for ATP production, whereas during heart failure (HF) glucose utilization increases, implying pathological changes to cardiac energy metabolism. Despite the noted lipotoxic effects of elevating FA, our work has demonstrated a cardioprotective effect of a high fat diet (SAT) when fed after myocardial infarction (MI), as compared to normal chow...
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