Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation.

doi:10.1161/CIRCEP.108.779181

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Article

Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation.

Circulation. Arrhythmia and electrophysiology - 1 Jun 2009

Watanabe Hiroshi, Darbar Dawood, Kaiser Daniel W, Jiramongkolchai Kim, Chopra Sameer, Donahue Brian S, Kannankeril Prince J, Roden Dan M

Abstract excerpt

BACKGROUND: We and others have reported mutations in the cardiac predominant sodium channel gene SCN5A in patients with atrial fibrillation (AF). We also have reported that SCN1B is associated with Brugada syndrome and isolated cardiac conduction disease. We tested the hypothesis that mutations in the 4 sodium channel beta-subunit genes SCN1B-SCN4B contribute to AF susceptibility. METHODS AND RESULTS: Screening...

Topics

Adult
Animals
Atrial Fibrillation
CHO Cells
Cricetinae
Cricetulus
Electrocardiography
Female
Genetic Predisposition to Disease
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation, Missense

Phenotype

Reverse Transcriptase Polymerase Chain Reaction

Sodium Channels

Structure-Activity Relationship

Source

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Identifiers

PMID: 19808477
DOI: 10.1161/CIRCEP.108.779181
PMCID: PMC2727725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19808477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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