Article
Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
Circulation. Arrhythmia and electrophysiology - 1 Dec 2016
Bao Yangyang, Willis B Cicero, Frasier Chad R, Lopez-Santiago Luis F, Lin Xianming, Ramos-Mondragón Roberto, Auerbach David S, Chen Chunling, Wang Zhenxun, Anumonwo Justus, Valdivia Héctor H, Delmar Mario, Jalife José, Isom Lori L
Abstract excerpt
BACKGROUND: Mutations in SCN2B, encoding voltage-gated sodium channel β2-subunits, are associated with human cardiac arrhythmias, including atrial fibrillation and Brugada syndrome. Because of this, we propose that β2-subunits play critical roles in the establishment or maintenance of normal cardiac electric activity in vivo. METHODS AND RESULTS: To understand the pathophysiological roles of β2 in the heart, we...
Topics
- Action Potentials
- Animals
- Atrial Fibrillation
- Blotting, Western
- Cells, Cultured
- Gene Deletion
- Genetic Predisposition to Disease
- Heart Conduction System
- Mice
- Monocytes