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Article

Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation.

International journal of molecular medicine - 1 Jul 2013

Li Ruo-Gu, Wang Qian, Xu Ying-Jia, Zhang Min, Qu Xin-Kai, Liu Xu, Fang Wei-Yi, Yang Yi-Qing

Abstract excerpt

Atrial fibrillation (AF) represents the most common form of sustained cardiac arrhythmia and accounts for substantial morbidity and mortality. Mutations in the cardiac sodium channel α, β1, β2 and β3 subunit genes (SCN5A, SCN1B, SCN2B and SCN3B) have been associated with AF, which suggests that mutations in the sodium channel β4 subunit gene, SCN4B, are also involved in the pathogenesis of AF. To examine this...

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Identifiers

PMID: 23604097
DOI: 10.3892/ijmm.2013.1355

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