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Article

Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block.

Circulation - 22 Jan 2002

Wang Dao W, Viswanathan Prakash C, Balser Jeffrey R, George Alfred L, Benson D Woodrow

Abstract excerpt

BACKGROUND: Three distinct cardiac arrhythmia disorders, the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with heterozygous mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A). We present clinical, genetic, and biophysical features of 2 new SCN5A mutations that result in atrioventricular (AV) conduction block. Methods and Results- SCN5A was...

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PMID: 11804990
DOI: 10.1161/hc0302.102592

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