Article
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block.
Circulation - 22 Jan 2002
Wang Dao W, Viswanathan Prakash C, Balser Jeffrey R, George Alfred L, Benson D Woodrow
Abstract excerpt
BACKGROUND: Three distinct cardiac arrhythmia disorders, the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with heterozygous mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A). We present clinical, genetic, and biophysical fe...
Topics
- Action Potentials
- Adult
- Amino Acid Sequence
- Atrioventricular Node
- Cell Line
- Child
- Computer Simulation
- Electrocardiography
- Female
- Heart Block
- Humans
- Kinetics
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Patch-Clamp Techniques