Article
Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population.
Biochemical and biophysical research communications - 16 Jul 2010
Wang Pengyun, Yang Qinbo, Wu Xiaofen, Yang Yanzong, Shi Lisong, Wang Chuchu, Wu Gang, Xia Yunlong, Yang Bo, Zhang Rongfeng, Xu Chengqi, Cheng Xiang, Li Sisi, Zhao Yuanyuan, Fu Fenfen, Liao Yuhua, Fang Fang, Chen Qiuyun, Tu Xin, Wang Qing K
Abstract excerpt
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for more than 15% of strokes. Mutations in cardiac sodium channel alpha, beta1 and beta2 subunit genes (SCN5A, SCN1B, and SCN2B) have been identified in AF patients. We hypothesize that mutations in the sodium channel beta3 subunit gene SCN3B are also associated with AF. To test this hypothesis, we carried out a large scale...
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