Article
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
PLoS pathogens - 2 Sept 2010
Ahn Sun-Hee, Deshmukh Hitesh, Johnson Nicole, Cowell Lindsay G, Rude Thomas H, Scott William K, Nelson Charlotte L, Zaas Aimee K, Marchuk Douglas A, Keum Sehoon, Lamlertthon Supaporn, Sharma-Kuinkel Batu K, Sempowski Gregory D, Fowler Vance G
Abstract excerpt
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that loci on chromosomes 8, 11, and 18 influence susceptibility to S. aureus sepsis in A/J mice. We then used two candidate gene selection strategies to...
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