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Article

Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis.

The Journal of biological chemistry - 20 Nov 2009

Diani Laura, Colombelli Claudia, Nachimuthu Benjamin Tamilselvan, Donnianni Roberto, Plevani Paolo, Muzi-Falconi Marco, Pellicioli Achille

Abstract excerpt

Rad53 is an essential protein kinase governing DNA damage and replication stress checkpoints in budding yeast. It also appears to be involved in cellular morphogenesis processes. Mass spectrometry analyses revealed that Rad53 is phosphorylated at multiple SQ/TQ and at SP/TP residues, which are typical consensus sites for phosphatidylinositol 3-kinase-related kinases and CDKs, respectively. Here we show that...

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Identifiers

PMID: 19801655
DOI: 10.1074/jbc.M109.048157
PMCID: PMC2781677

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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