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Article

Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.

Molecular biology of the cell - 1 Dec 2002

Moore Jonathan D, Kornbluth Sally, Hunt Tim

Abstract excerpt

Cyclin-dependent kinase (Cdk)2/cyclin E is imported into nuclei assembled in Xenopus egg extracts by a pathway that requires importin-alpha and -beta. Here, we identify a basic nuclear localization sequence (NLS) in the N-terminus of Xenopus cyclin E. Mutation of the NLS eliminated nuclear accumulation of both cyclin E and Cdk2, and such versions of cyclin E were unable to trigger DNA replication. Addition of a...

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Identifiers

PMID: 12475960
DOI: 10.1091/mbc.e02-07-0449
PMCID: PMC138641

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Source receipt: pubmed, retrieved 7 Sept 2026.

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