Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphism of catechol O-methyltransferase and pharmacokinetics of levodopa in healthy Chinese subjects.

Methods and findings in experimental and clinical pharmacology - 1 Jan 2000

Lin C-H, Wang C-L, Huang P-F, Liu Y-W, Ke M, Xu Y, Yu C-X

Abstract excerpt

We studied the distribution of catechol O-methyltransferase (COMT) genotypes in the Chinese Fujian Han population and explored the potential effect of COMT genetic polymorphism on the pharmacokinetics of levodopa. Polymerase chain reaction (PCR) was employed in the COMT genotype analysis of 166 volunteers. After a single oral dose of levodopa/benserazide, the plasma concentration of levodopa was determined by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiparkinson Agents
Share to Area Under Curve

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Chromatography, High Pressure Liquid

Share to Drug Combinations

Share to Half-Life

Share to Levodopa

Share to White People

Source

Identifiers

PMID: 19798454
DOI: 10.1358/mf.2009.31.6.1386990

Genes

COMT
ECD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphism of catechol O-methyltransferase and pharmacokinetics of levodopa in healthy Chinese subjects.PMID 19798454Read ↗

Catechol-O-methyltransferase and Parkinson's disease.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population.Semantic proximity Read ↗

Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease.Semantic proximity Read ↗

Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson’s diseaseSemantic proximity Read ↗

Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease.Semantic proximity Read ↗

Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease.Semantic proximity Read ↗

Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.Semantic proximity Read ↗

No association between catechol-O-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children.Semantic proximity Read ↗

[Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease].Semantic proximity Read ↗

Val158Met polymorphisms of COMT gene and serum concentrations of catecholaminergic neurotransmitters of ADHD in Chinese children and adolescents.Semantic proximity Read ↗

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.Semantic proximity Read ↗

Association of Catechol-O-Methyltransferase Gene rs4680 Polymorphism and Levodopa Induced Dyskinesia in Parkinson's Disease: A Meta-Analysis and Systematic Review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.