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Article

Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease.

Neuroscience letters - 2 Feb 2001

Lee M S, Lyoo C H, Ulmanen I, Syvänen A C, Rinne J O

Abstract excerpt

A single nucleotide polymorphism at the nucleotide 1947 in the catechol-O-methyltransferase (COMT) gene encodes the high and low activity forms of the enzyme. We investigated COMT genotypes of 73 Korean patients with Parkinson's disease (PD), 29 with multiple system atrophy (MSA), and 49 controls, and analyzed the response to levodopa challenge in the PD patients. We found no significant difference in the...

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Source

Identifiers

PMID: 11163295
DOI: 10.1016/s0304-3940(00)01749-3

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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