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Article

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

2 Oct 2009

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by a block in differentiation and accumulation of promyelocytes in the bone marrow and blood. The majority of APL patients harbor the t(15:17) translocation leading to expression of the fusion protein promyelocytic-retinoic acid receptor alpha. Treatment with retinoic acid leads to degradation of promyelocytic-retinoic acid receptor alpha protein and...

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PMID: 19797526
DOI: 10.1182/blood-2008-10-182071

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