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Cell differentiation in acute myeloid leukemia

1 Jul 1996

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by a differentiation block leading to accumulation of immature cells. Chromosomal translocations in AML affect transcription factors that are involved in regulation of myeloid differentiation. Aberrant expression of these factors interferes with differentiation events and has a role in the pathogenesis of AML through superactivation or (dominant negative) repression...

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PMID: 8698118
DOI: 10.1111/j.1600-0609.1996.tb00483.x

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