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Article

Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.

Genetics - 1 Dec 2009

Locke Cody J, Kautu Bwarenaba B, Berry Kalen P, Lee S Kyle, Caldwell Kim A, Caldwell Guy A

Abstract excerpt

The nerve-cell cytoskeleton is essential for the regulation of intrinsic neuronal activity. For example, neuronal migration defects are associated with microtubule regulators, such as LIS1 and dynein, as well as with actin regulators, including Rac GTPases and integrins, and have been thought to underlie epileptic seizures in patients with cortical malformations. However, it is plausible that post-developmental...

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Identifiers

PMID: 19797046
DOI: 10.1534/genetics.109.106880
PMCID: PMC2784297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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