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Article

Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae.

Cell - 30 Nov 1990

McGinnis N, Kuziora M A, McGinnis W

Abstract excerpt

Within the serial array of vertebrate homeobox genes in the Hox complexes, it is possible to define a subgroup that is structurally homologous to the Drosophila homeotic gene Deformed (Dfd). We wished to test whether a vertebrate Dfd-like protein could substitute for any of the regulatory functions of the Dfd protein in Drosophila embryos, including its ability to transcriptionally activate the Dfd transcription...

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Source

Identifiers

PMID: 1979526
DOI: 10.1016/0092-8674(90)90500-e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae.PMID 1979526Read ↗

A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development.Semantic proximity Read ↗

A cap 'n' collar protein isoform contains a selective Hox repressor function.Semantic proximity Read ↗

Establishment of the Deformed expression stripe requires the combinatorial action of coordinate, gap and pair-rule proteins.Semantic proximity Read ↗

A screen for modifiers of Deformed function in Drosophila.Semantic proximity Read ↗

Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide.Semantic proximity Read ↗

Autocatalysis and phenotypic expression of Drosophila homeotic gene Deformed: its dependence on polarity and homeotic gene function.Semantic proximity Read ↗

Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.Semantic proximity Read ↗

A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function.Semantic proximity Read ↗

Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development.Semantic proximity Read ↗

Switching the in vivo specificity of a minimal Hox-responsive element.Semantic proximity Read ↗

Ectopic expression from the Deformed gene triggers a dominant defect in Drosophila adult head development.Semantic proximity Read ↗

Expression of the human FUSED protein in Drosophila.Semantic proximity Read ↗

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