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Article

Implication of the HLA-DRB3 gene in Graves' disease: predominance of allele Dw24.

Human immunology - 1 Oct 1990

Semana G, Allanic H, Quillivic F, Vallejo M T, Simon J P, Genetet B, Fauchet R

Abstract excerpt

Using RFLP, the present study sets off to determine the MHC class II gene polymorphism in Graves' disease, in order to define the HLA-related genetic susceptibility. Considering the preferential link between Graves' disease and the HLA-DR3 antigen, 42 HLA-DR3 Graves' disease patients were studied and compared with 42 HLA-DR-matched controls. Hybridization with a DQ alpha probe of DNAs digested by Taq I revealed a...

Topics

Alleles
Autoimmune Diseases
Deoxyribonucleases, Type II Site-Specific
Disease Susceptibility
Gene Frequency
Genes, MHC Class II
Genotype
Graves Disease
HLA-DQ Antigens
HLA-DR Antigens
HLA-DR Serological Subtypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Phenotype

Polymorphism, Restriction Fragment Length

Risk Factors

Source

Identifiers

PMID: 1979072
DOI: 10.1016/0198-8859(90)90077-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979072-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Implication of the HLA-DRB3 gene in Graves' disease: predominance of allele Dw24.PMID 1979072Read ↗

HLA-DRB3 gene alleles in Caucasian patients with Graves' disease.Semantic proximity Read ↗

Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population.Semantic proximity Read ↗

Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds.Semantic proximity Read ↗

HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective.Semantic proximity Read ↗

HLA-DRB3*0101 is associated with Graves' disease in Jamaicans.Semantic proximity Read ↗

The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans.Semantic proximity Read ↗

Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease.Semantic proximity Read ↗

Primary role of the HLA class II DRB1*0301 allele in Graves disease.Semantic proximity Read ↗

Rapid and simple subtyping of the HLA-DRB3 gene in Graves' disease by using temperature-gradient gel electrophoresis.Semantic proximity Read ↗

Two HLA DRB 1 alleles confer independent genetic susceptibility to Graves disease: relevance of cross-population studies.Semantic proximity Read ↗

HLA DQA1*0501 and DRB1*0301 antigens do not independently convey susceptibility to Graves' disease.Semantic proximity Read ↗

Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: replication using a population case control and family-based study.Semantic proximity Read ↗

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